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PAI-1, a serine protease inhibitor and another factor involved in the pathogenesis of stroke is produced primarily by the endothelium which directly acts as an active inhibitor of tPA and urokinase (uPA), a serine protease which is responsible for cleaving plasminogen to plasmin (Lakhan et al., 2013)

ClinicalTrials.gov (2026) Related Dosing Protocols Educational use only This guide is an educational research reference, not medical advice or a treatment plan

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Advantage: Potential for higher bioavailability than standard oral ingestion Challenge: Peptides are poorly absorbed through intact mucosal membranes without transport mechanisms Evidence: No studies confirm enhanced sublingual bioavailability for Dihexa Standard oral (swallowed): Tablets swallowed with water, absorbed through the gastrointestinal tract